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Progressive Neurodegeneration From Anoxic Injury Following Perioperative Cardiac Arrest
20+ hour, 1+ min ago (188+ words) Severe hypoxic-ischemic brain injury following cardiac arrest can result in persistent and evolving neurologic, cognitive, and visual impairment, with later clinical decline that may be difficult to distinguish from superimposed neurodegenerative disease. A prolonged and evolving pattern of neurologic, cognitive,…...
Progressive Slurred Speech as an Atypical Presentation of GDAP2-Related Spinocerebellar Ataxia: A Case Report
1+ mon, 20+ hour ago (167+ words) A 47-year-old man with diabetes mellitus and dyslipidemia developed progressive slurred speech over four years. MRI revealed no cerebellar atrophy, and routine laboratory and neurophysiological investigations were unremarkable. His brother exhibited similar but advanced symptoms, including dysphagia and severe gait…...
Butterfly Glioma of the Corpus Callosum Mimicking Rapidly Progressive Dementia
1+ mon, 4+ week ago (261+ words) A butterfly-pattern, high-grade glioma involving the corpus callosum is an uncommon but highly aggressive brain tumour that may present with neuropsychiatric manifestations and mimic rapidly progressive dementia, leading to diagnostic delay. Disruption of frontal-callosal connectivity may produce behavioural and cognitive…...